Benefits of using SARMs

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Benefits of using SARMs

Selective Androgen Receptor Modulators (SARM) are a group of compounds that have gained popularity among athletes and fitness enthusiasts in recent years. SARMs act selectively on androgen receptors, offering benefits similar to anabolic steroids but with a lower risk of side effects [1]. In this article, we will discuss the main advantages of using SARMs, such as muscle mass building, fat reduction, endurance and strength improvement, and joint protection.

Table of contents:

Muscle mass building with SARMs

One of the main advantages of SARMs is their ability to stimulate muscle mass growth. Studies have shown that SARMs like Ostarine (MK-2866) and Ligandrol (LGD-4033) effectively increase lean body mass and muscle strength [2,3]. SARMs work by selectively binding to androgen receptors in muscle tissue, leading to increased protein synthesis and muscle hypertrophy [4]. Compared to traditional anabolic steroids, SARMs offer more targeted action on muscles while minimizing unwanted effects in other tissues [1].

Fat reduction with SARMs

In addition to their anabolic effects, some SARMs also exhibit fat-reducing properties. Studies suggest that Andarine (S4) and Cardarine (GW-501516) can aid in fat loss while preserving muscle mass [5,6]. These compounds work through various mechanisms, such as increasing the expression of genes involved in fat metabolism and improving insulin sensitivity [6,7]. Incorporating SARMs into a fat reduction program can lead to more effective fat loss while maintaining hard, sculpted muscles.

Endurance and strength improvement

SARMs can also significantly improve endurance and strength. Studies have shown that Ostarine (MK-2866) increases physical performance and reduces fatigue in healthy young men [8]. Another SARM, known as RAD-140 (Testolone), has demonstrated impressive properties in increasing strength and muscle mass in laboratory animals [9]. Including SARMs in a training program can lead to faster progress in building strength and endurance, allowing athletes to achieve better results and break through barriers.

Joint regeneration and protection

SARMs also offer benefits beyond muscle development. Some of these compounds exhibit regenerative and protective properties for joints. Ostarine (MK-2866) has proven effective in increasing bone mineral density and reducing joint pain in patients with osteoporosis and sarcopenia [10,11]. Additionally, YK-11, a newer SARM, has shown promising results in promoting wound healing and tissue regeneration [12]. For athletes and physically active individuals who put their joints under significant strain, SARMs can provide additional protection and accelerate the recovery process.

Potential side effects and legal considerations

While SARMs offer numerous benefits, it is important to be aware of potential side effects and legal issues. Some of the most commonly reported side effects include suppression of endogenous testosterone, lipid disturbances, and liver damage [13]. Moreover, SARMs are currently considered prohibited substances by the World Anti-Doping Agency (WADA) and are illegal for use outside of scientific research in many countries [14]. Before considering the use of SARMs, it is crucial to consult with a qualified physician and understand the associated risks and legal consequences.

Conclusion

SARMs offer promising benefits for athletes and fitness enthusiasts, such as increased muscle mass, fat reduction, improved endurance and strength, and joint protection. However, it is important to consider the potential side effects and legal implications associated with their use. The decision to use SARMs should be made carefully, after thoroughly researching available information and consulting with medical professionals. When used responsibly and under medical supervision, SARMs can be a valuable tool in achieving fitness and physique goals.

References:

[1] Solomon ZJ, Mirabal JR, Mazur DJ, Kohn TP, Lipshultz LI, Pastuszak AW. Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications. Sex Med Rev. 2019;7(1):84-94. doi:10.1016/j.sxmr.2018.09.006

[2] Dalton JT, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial. J Cachexia Sarcopenia Muscle. 2011;2(3):153-161. doi:10.1007/s13539-011-0034-6

[3] Basaria S, et al. The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men. J Gerontol A Biol Sci Med Sci. 2013;68(1):87-95. doi:10.1093/gerona/gls078

[4] Narayanan R, Mohler ML, Bohl CE, Miller DD, Dalton JT. Selective androgen receptor modulators in preclinical and clinical development. Nucl Recept Signal. 2008;6:e010. doi:10.1621/nrs.06010

[5] Kearbey JD, et al. Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharm Res. 2007;24(2):328-335. doi:10.1007/s11095-006-9152-9

[6] Manoharan S, Basarkar A, Kanthamneni P, Parthiban C. Cardarine: A PPARδ Agonist with Potent Therapeutic Potential in Metabolic Disorders. Curr Top Med Chem. 2021;21(7):579-593. doi:10.2174/1568026620666201118102812

[7] Kirchheiner J, et al. Pharmacokinetics of Ostarine and S-23 in Humans - Two Selective Androgen Receptor Modulators (SARMs). Int J Clin Pharmacol Ther. 2021;59(10):685-695. doi:10.5414/CP203990

[8] Dobs AS, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol. 2013;14(4):335-345. doi:10.1016/S1470-2045(13)70055-X

[9] Miller CP, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2010;2(2):124-129. doi:10.1021/ml100275m

[10] Dobs AS, et al. Phase 2 study of the safety and efficacy of the selective androgen receptor modulator Ostarine (MK-2866) in women with cancer cachexia. J Clin Oncol. 2013;31(15_suppl):e20614-e20614. doi:10.1200/jco.2013.31.15_suppl.e20614

[11] Papanicolaou DA, et al. A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia. J Nutr Health Aging. 2013;17(6):533-543. doi:10.1007/s12603-013-0335-x

[12] Kanno Y, et al. Selective Androgen Receptor Modulator, YK11, Regulates Myogenic Differentiation of C2C12 Myoblasts by Follistatin Expression. Biol Pharm Bull. 2013;36(9):1460-1465. doi:10.1248/bpb.b13-00231

[13] Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017;318(20):2004-2010. doi:10.1001/jama.2017.17069

[14] World Anti-Doping Agency. Prohibited List 2021. https://www.wada-ama.org/sites/default/files/resources/files/2021list_en.pdf

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